All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.


Synthesis and characterization of chitosan nanoparticles as perspective drug delivery carrier: Study of their degradation, antibacterial activity and in-vitro blood compatibility behavior

Author(s): Hemlata Bundela, A.K. Bajpai, Vishal Bharadwaj

Chitosan-TPP nanoparticles have been prepared using ionotropic crosslinking method. FTIR results show characteristic peaks of functional groups present in the nanoparticles. XRD studies revealed about 44.6 % crystallinity of chitosan-TPP nanoparticle material. SEM and TEM studies show the spherical shape of the particles with 20-90 nmsize. Swelling ratio of the particles in PBS and SBFwas found to be in the range of 0.55-3.36 and 2.66- 4.19 respectively.%degradation of thematerial in PBS and in presence of enzyme papain has been calculated 46.6%and about 80.0%respectively. In-vitro blood protein adsorption for the nanoparticles was found to be in the range of 0.052-0.351mg/g and%haemolysiswas found to be in between 3.31- 42.1%.Antibacterial activity of thematerialwas checked against strain of E.Coli and Bacillus Cereus and percent inhibition of bacterial growth was found in the range of 11-35 %.

Share this       

Share this Page.

Table of Contents

izmir escort izmir escort bursa escort antalya escort izmir escort porno porno izle türk porno eskişehir escort bartın escort burdur escort havalandırma izmir escort bursa escort porno indir izle escort izmir