Environmentally benign synthesis of bis(indolyl)methanes using sulfatedmesoporous titania as a catalyst

Author(s): Babita Sehgal

Bis(indolyl)methanes, and their derivatives are known as important intermediates in organic synthesis and pharmaceutical chemistry. An efficient and an environmentally benign route for the synthesis of bis(indol-3- yl)methane derivatives (3) has been achieved by one pot, two component condensation reaction of derivatives of aldehydes (1) with indole (2) in presence of sulfated titania.Modification by sulphate ion cause an increase in acidity of titania so as to make it an efficient, reusable, and cheap catalyst giving high yields of bis(indol-3-yl)methanes.

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