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Genetic Biomarker

A bio-marker, or organic marker is a quantifiable pointer of some natural state or condition. Biomarkers are frequently estimated and assessed to look at typical natural procedures, pathogenic procedures, or pharmacologic reactions to a restorative intervention. Biomarkers are utilized in numerous logical fields. Biomarkers for precision medicine are a neighborhood of a comparatively new clinical toolset. In the case of metastatic colorectal cancer (mCRC) only two predictive biomarkers have thus far been identified and implemented clinically. During this case, the shortage of knowledge beyond retrospective studies and successful biomarker-driven approaches was suggested to be principal cause behind a requirement for novel biomarker studies within the medical field thanks to the severe attrition that accompanies clinical trials.The field of biomarker research is additionally expanding to incorporate a combinatorial approach to identifying biomarkers from multi-omic sources. Combining groups of biomarkers from various omic data allows for the likelihood of developing panels that evaluate treatment response supported many biomarkers at one time. One such area of expanding research in multi-omic biomarkers is mitochondrial DNA sequencing. Mutations in mitochondrial DNA have been shown to correlate to risk, progression, and treatment response of head and neck squamous cell carcinoma.    

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