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Flunitrazepam Journals

 Flunitrazepam as with additional benzodiazepines can principal to drug need. Discontinuation may result in the appearance of withdrawal symptoms. Abrupt withdrawal may lead to a benzodiazepine withdrawal syndrome characterised by seizures, psychosis, insomnia, and anxiety. Rebound insomnia, inferior than baseline insomnia, characteristically happens after cessation of flunitrazepam even from short-term single nightly dose therapy. Flunitrazepam may reason a paradoxical response in some persons causing symptoms including anxiety, aggressiveness, agitation, confusion, disinhibition, loss of impulse control, talkativeness, violent behavior, and even convulsions. Paradoxical adverse belongings may smooth principal to criminal behaviour. Benzodiazepines such as flunitrazepam are lipophilic and fast enter membranes and, so, fast cross over into the placenta with significant uptake of the drug. Use of benzodiazepines including flunitrazepam in late pregnancy, especially high doses, may result in hypotonia, also known as floppy baby syndrome.

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