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, Volume: 17( 2)

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Physical Properties and Phase Solubility Studies of Sulfadiazine Schiff Bases Inclusion Complexes with β-Cyclodextrine

Physical Properties and Phase Solubility Studies of Sulfadiazine Schiff Bases Inclusion Complexes with ?-Cyclodextrine Jabbar Saleh Hadi* and Noor Ali Abdul Alrazaq 1Department of Chemistry, College of Education for Pure Science, Basrah University- Basrah- IRAQ *Corresponding author: Jabbar Saleh Hadi, Department of Chemistry, College of Education for Pure Science, Basrah University- Basrah- IRAQ, Tel: 9647710822193; E-Mail: jshalkabi2@gmail.com Received: August 02, 2022, Manuscript No. TSPCAI-22-62624; Editor assigned: August 04, 2022, PreQC No. TSPCAI-22-62624(PQ); Reviewed: August 18, 2022, QC No. TSPCAI-22-62624; Revised: August 25, 2022, Manuscript No. TSPCAI-22- August 31, 2022, DOI: 10.37532/tspcai.2022.17(2).001

Abstract

A novel inclusion Complex of Sulfadiazine Schiff bases with βCyclodextrine were Prepared , the formation of inclusion Complexes has been studied by IR ,HNMR ,SEM and XRD methods , The improvement of Solubility of Schiff bases and the 1:1 stoichiometry of the Complexes was Confirmed followed Higuchi and Connors method . The amorphous nature of the resulting inclusion Complexes were confirmed by SEM and XRD . The crystallite size of Schiff bases and the corresponding inclusion complexes were determined using Willamson –Hall method

Abstract A novel inclusion Complex of Sulfadiazine Schiff bases with ?Cyclodextrine were Prepared , the formation of inclusion Complexes has been studied by IR ,HNMR ,SEM and XRD methods , The improvement of Solubility of Schiff bases and the 1:1 stoichiometry of the Complexes was Confirmed followed Higuchi and Connors method . The amorphous nature of the resulting inclusion Complexes were confirmed by SEM and XRD . The crystallite size of Schiff bases and the corresponding inclusion complexes were determined using Willamson ?Hall method Keywords: Sulfa drugs; Freezdrying; Higuchi-Connors; Willamson ?Hall; SEM Introduction Schiff bases are compounds containing azomethine group resulting from condensation of primary amines with carbonyl compounds. Schiff bases exhibit many applications such as used to development various bioactive compounds that are used in pharmaceutical industry. They are used as antimicrobial, antioxidant, anticonvulsant ets . Schiff bases also used in industry as a catalyst, anticorrosion inhibitors and in dye and pigments industries [1]. ?-Cyclodextrine is one of macrocyclic oligosaccharides consist of seven glucopyranose units joined together via ?-1,4 glycosidic bonds to formation a cone shaped structure with a hydrophobic nature cavity and hydrophilic outer surface , by this coracterstic structure cyclodextrines are able to formation inclusion Complexes , and the purpose of Preparation of inclusion Complexes to improved chemical , physical and biological properties compared to the guest molecules , for example increase the aqueous solubility increase the stability against oxidation or photo decomposition ets . [2]. Abstract A novel inclusion Complex of Sulfadiazine Schiff bases with ?Cyclodextrine were Prepared , the formation of inclusion Complexes has been studied by IR ,HNMR ,SEM and XRD methods , The improvement of Solubility of Schiff bases and the 1:1 stoichiometry of the Complexes was Confirmed followed Higuchi and Connors method . The amorphous nature of the resulting inclusion Complexes were confirmed by SEM and XRD . The crystallite size of Schiff bases and the corresponding inclusion complexes were determined using Willamson ?Hall method Keywords: Sulfa drugs; Freezdrying; Higuchi-Connors; Willamson ?Hall; SEM An Indian Journal 62624(R); Published: www.tsijournals.com | August-2022 2 Materials and Methods Materials: Sulfadiazine was purchased from Sigma ? Aldrich Company, Salcildehyde and 2- hydroxy naphthaldehyde were purchased from BDH, ?-CD was obtained from Across Organic Company. All solvent used are of analytical grad and used as received without further Purification [3]. Spectral measurement: IR spectra were recorded as KBr Pellets on Shimadzu FTIR-8300 spectrophotometer in the region 4000?400 cm-1. 1 HNMR were recorded as DMSO-d6 solution at room temperature on a Brucker 500 (500 MHz) TMS as internal reference. EI - Mass Spectra were recorded on Agilent Technologies 5975C Spectrometer. XRD Patterns were recorded on Panalytical X ? PERT Panalytical X ? PERT PRO ,( Panalytical Company) , Netherlands using Cu K? radiation (?=1.54060