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Synthetic, Spectroscopic and Antimicrobial Studies of Mannich Bases Through Active Hydrogen Compounds

Author(s): S. Joshi, Anju Das Manikpuri and Deepak Khare

The purpose of this study was to prepare a targeted series of Mannich bases by introducing the 2-chloro 4-nitrobenzamide and 2-methylbenzamide pharmacophore into secondary amines for study of their biological effects. The structures of the synthesized compounds were assigned on the basis of elemental analyses, UV, IR and 1H NMR spectral studies. The biological screening of these synthesized compounds were done against various Gram- positive and Gram-negative bacteria with a view to explore their antimicrobial action by disk diffusion method at 40, 80 and 160 mg/mL, respectively. The results demonstrate the potential and importance of mounting new Mannich bases against pathogens under investigation and found to be low toxic as ascertained by LD50 test.

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