All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Synthesis, Characterization and Antimicrobial Study of 1, 2-Disubstituted Benzimidazoles

Author(s): Girija K and Indhumathi S

A series of novel disubstituted benzimidazole derivatives were synthesized by condensation of o-phenylenediamine with different aromatic aldehydes in presence of ceric ammonium nitrate forming 2-substituted benzimidazoles which on further condensation with secondary amine and formaldehyde forms 1, 2-disubstituted benzimidazoles. The purity of the synthesized compounds was monitored by thin layer chromatography and characterized by FT-IR, 1HNMR, MASS spectral analysis. The compound exhibited moderate antibacterial activity against Bacillus subtilis, good activity against Escherichia coli, compared to standard ciprofloxacin. The two synthesized compounds named 3a [ (2-{[2-(3-chlorophenyl)-1H-benzimidazol-1-yl] methyl}-1H-isoindole-1, 3(2H)-dione)] and 5a [2-{[2-(2-chlorophenyl)-1H-benzimidazol-1-yl] methyl}-1H-isoindole-1, 3(2H)-dione] were tested for the antitubercular activity showed a significant activity against Mycobacterium tuberculosis (H37Rv).


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More