Synthesis, Antimicrobial and Antifungal Study of 2-(5–Aryl-1-substituted-pyrazol-3-yl)-substituted naphthalene-1-ol by Dehydrogenation Method

Author(s): B. P. Khobragade and P. T. Kosankar

2-(5-aryl-4,5-dihydro-1-substituted-pyrazol-3-yl)-substituted naphthalene-1-ol were suspended in DMSO and crystal of iodine was added to it. The mixture was refluxed for 1½ hour, cooled and then diluted with water. The solid mass obtained was filtered, washed with 10% aqueous sodium thiosulphate and crystallized from ethanol acetic acid mixture to get 2-(5–aryl-1-substituted-pyrazol-3-yl)-substituted naphthalene-1-ol. The synthesized compounds are characterized by elemental analysis, 1H NMR, IR spectroscopy. Newly synthesized compound shows an excellent antimicrobial and antifungal activities.

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