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Synthesis and Biological Evaluation of Some Substituted Phenyl Thiazolyl Naphthyl Methanone Derivatives

Author(s): C Brilla1, TF Abbs Fen Reji2*

Phenylthiazolylnaphthylmethanone and their analogues serve as precursors for the synthesis of biologically active compounds. They were accounted for to have antimicrobial, analgesic, anti-inflammatory, anticonvulsant, cardiotonic, anticancer, anti-tubercular and anthelmintic activities. The Phenylthiazolylnaphthylmethanone derivatives were synthesized and characterized by FT-IR, 1H NMR, 13C NMR, Mass spectral studies and biological studies. In addition, the Lipinski rule of five, molecular docking was used to calculate binding affinities and predict binding locations for the various receptors. With an end goal to assess and plan quick, precise Density Functional Theory (DFT) strategies for the compound was finished utilizing Gaussion' 09 program using B3LYP technique with the 6-31G premise set. The antioxidant activity has been analyzed using the DPPH radical scavenging assay. Among the (2-diethylamino-4-phenylthiazol-5-yl-2-naphthyl) methanone (1b) was highly active on the SKMEL cell line.

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  • Geneva Foundation for Medical Education and Research

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