Structural and Biological Activities of (4Z)-4-(3-Phenyl allylidene amino)-3-Hydroxy Naphthalene-1-Sulfonic Acid (AC) and Naphthalene-1-Yl-Thiophene-2-Ylmethylene-Amine (NT) as Schiff Bases

Author(s): S. Thirugnanaselvi and S. Kuttirani, I. Mohammed Bilal and D. Easwaramoorthy

Schiff bases (4Z)-4-(3-phenyl allylidene amino)-3-hydroxy naphthalene-1-sulfonic acid (AC) and naphthalene-1-yl-thiophene-2-ylmethylene-amine (NT) derived from the condensation reaction of Analar grade 1-amino-2-naphthol 4-sulphonic acid WITH Cinnamaldehyde and naphthalene-1-ylamine and thiophene-2-carboxaldehyde, respectively was prepared. The synthesis was carried out under microwave condition. This Schiff base was analysed by infra-red and UV. The all prepared compounds were assayed for antibacterial (Bacillus subtilis MTCC 441, Staphylococcus aureus MTCC 96, Echirichia coli MTCC 1689 and Proteus vulgaris MTCC 742) and antifungal (Aspergillus sp. and Candida albicans) activities by disc diffusion method. The results indicate that all tested compounds show antibacterial activity against E. coli, as gram positive and negative bacteria, and antifungal activity against C. albicans. But the compounds AC having 1-OH and 1-HSO3 substituted showed good inhibition against bacteria and fungi as compare to standard drugs.

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