Solvent Free Synthesis and Biological Evaluation of 1, 5-Benzodiazepine

Author(s): Nachiket SD, Atul KW and Deepak SM

Number of substituted 1, 5-benzodiazepines are known for their biological importance like anti-bacterial, antifungal, anticancer, and anti-inflammatory activity. The present investigation is carried for the synthesis of certain substituted 1, 5-benzodiazepines and carried out their sedative activity. The title compounds have been synthesized from OPD reacts with substituted aryl aldehydes to give substituted 1, 5-benzodiazepines. The newly synthesized compounds have been characterized by IR, 1H NMR and CHN analysis. Selected compounds are screened for sedative activity in vivo using spontaneous locomotor activity model. Few of them exhibited promising activity.

Share this       
izmir escort izmir escort bursa escort antalya escort izmir escort porno porno izle türk porno eskişehir escort bartın escort burdur escort izmir escort bursa escort porno indir izle istanbul escort istanbul escort bayan escort izmir