Abstract

Quantification Method Development and Validation for Analysis of Rivastigmine in Bulk and Pharmaceutical Dosage Form by RP-HPLC

Author(s): K. S. Nataraj, S. Suresh Kumar, M. Badrud Duza and D. B. Raju

A rapid and precise reverse phase high performance liquid chromatographic method has been developed for the estimation of Rivastigmine in its pur e form as well as in pharmaceutical dosage forms. Chromatography was carried out on Inertsil, C-18, 250 x 4.6 mm. 5 μ using a mixture of Phosphate buffer and Acetonitrile (70 : 30 v/v) as the mobile phase at a flow rate of 1.0 mL/min the detection was done by UV at 217nm. The retention time of the drug was 3.66 ± 0.25 min min. The method produced linear responses in the concentration range of 10-100 μ g/mL of Rivastigmine. The method was found to be reproducible for analysis of the drug in tablet dosage forms


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