Novel Chalcones of 3-[4-(4-[4-Acetylphenoxy]-6-([Nitrophenyl]amino)-1,3,5-Triazin-2-yl)oxy)Phenyl]-1-(2,4-Dichlorophenyl)Prop-2-en-1-one for Biological Applications: Synthesis, Characterization and Antimicrobial Studies

Author(s): Bagyaraj E, Moorthi K and Aboobuckersithique M*

A series of bioactive chalcones are synthesized using 3-(4-(4-[4-acetylphenoxy]-6-([nitrophenyl]amino)-1,3,5-triazin-2-yl)oxy)phenyl)-1-(2,4-dichlorophenyl)prop-2-en-1-one (ACP) and different substituted aromatic aldehyde under solvent free conditions. Synthesized chalcones are characterized and tested for their antimicrobial activity against gram positive and gram negative bacteria’s. The synthesized chalcones are characterized by IR, 1H-NMR and UV-visible spectroscopic techniques. The antimicrobial activities of the chalcones are determined using minimum inhibitory concentration (MIC) method. Synthesized chalcones shows high activity against tested bacteria’s especially the chalcone containing chlorine moiety shows very high activity against tested gram positive bacteria Staphylococcus aureus at 7.81 μL/ml.

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