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New potentiometric determination of clindamycin hydrochloride in pharmaceuticals

Author(s): Mohamed S.Rizk, Hanan A.Merey, Shereen M.Tawakkol, Mona N.Sweilam*

A potentiometricmembrane sensor responsive with satisfactory selectivity to clindamycin hydrochloride was prepared for simple and fast determination of this drug in pure form and pharmaceutical dosage forms without prior extraction process or separation from different dosage form excipients. The sensor was based on the formation of an ion association complex between clindamycin hydrochloride as a cationic drug and sodium phosphotungestate as anionic electroactive material. The produced ion association complex was incorporated in plasticized polyvinyl chloride membrane. The performance characteristics of this sensors were evaluated according to IUPAC recommendations-reveal fast, stable and near Nernestian response for 3.16 × 10-4 - 1 × 10-1 M for clindamycin hydrochloride. Statistical comparison between the results obtained by applying the proposed potentiometric method for the determination of the clindamycin hydrochloride and those obtained by applying the official method was done and no significant difference was found at p = 0.05. Validation of themethod according to ICH guidelines shows the suitability of the sensor for quality control analysis of the cited drugs in pharmaceutical formulations. The proposed sensors can also be used as a detector for HPLCmethod.

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