7187379870

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Lipid lowering and antioxidant activity of rohitukine from Dysoxylum binectariferum in hyperlipidemic rats

Author(s): Vijai Lakshmi, Ashok Kumar Khanna, Abbas Ali Mahdi, Santosh Kumar Agarwal

The lipid lowering and antioxidant activity of rohitukine a pure compound isolated from the stem bark of the Dysoxylum binectariferum has been studied in triton and cholesterol fed hyperlipidemic rats (in vivo). Serum lipids were found to be lowered by rohitukine (at 200mg/kg.) in tritonWR- 1339 induced hyperlipidemia in experimental animals.. Chronic feeding of this compound (at 100 mg/kg) in animals simultaneously fed with high fat diet (HFD) for 30 days caused lowering in the lipid and apoprotein levels of very low density (VLDL) and low density lipoproteins (LDL) and increased high density lipoprotein (HDL). Rohitukine activated lipolytic enzymes in plasma and liver lipids. The hypolipidemic activity of the rohitukine is mediated through increased faecal bile acid excretion and enhanced plasma lecithin-cholesterol acyl transferase activity. This molecule showed potent antioxidant and oxygen free radical scavenging activity (in in vitro studies).


Share this       
Google Scholar citation report
Citations : 1106

Natural Products: An Indian Journal received 1106 citations as per Google Scholar report

Indexed In

  • CASS
  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Directory of Research Journal Indexing (DRJI)
  • Secret Search Engine Labs
  • Scholar Article Impact Factor (SAJI))
  • ICMJE

View More

Flyer