Limonoids as antidyslipidemic from the fruits of Xylocarpus molluccensis

Author(s): Vijai Lakshmi, Anju Puri

The ocean offers a rich source of structurally unique molecules providing novel plate form for drug discovery. The 95% ethanol extract of the epicarp of the fruits of X. molluccensis given orally at a dose of 500mg/kg showed significant antidyslipidemic activity in hamster model. Among the four fractions tested the chloroform soluble fraction showed highly significant lipid lowering activity at 50mg/kg. Further purification of chloroform fraction yielded four compounds. Out of four compounds bioevaluated, only one compound showed promising activity even at 25mg/ kg. dose.

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