In vitro and in vivo antiamoebic activity of the Heritiera littoralis Dry and against Entamoeba histolytica.

Author(s): Vijai Lakshmi, Sheela Ghoshal

Human amoebiasis due to Entamoeba histolytica infection is mainly associated withmorbidity thus affecting the quality of life and pace of developmental activities of countries withwarmclimatic conditions.Aconsistently high global incidence of this disease has been reported. In an endeavor to identify novel molecules with potent antiamoebic activity and lower sideeffect, the present study was designed to investigate antiamoebic activity in Heritiera littoralis extracts. The aqueous ethanol and aqueous extracts of the Heritiera littoralis showed promising in vitro and in vivo antiamoebic activity (MIC31.25 andAt 250mg/Kg dose 90%protection). Further work on pure molecules from this plant is in progress to get an antiamoebic lead molecule.

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