Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerFormulation and Evaluation of Ramipril Transdermal Patch| Abstract

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Abstract

Formulation and Evaluation of Ramipril Transdermal Patch

Author(s): P. Dwarakanadha Reddy, D. Swarnalatha, A. Dinakar, P. Naresh Babu, C. Raghunath Guptha, C. H. Venku Reddy, B. Sravani, S. Shankar Rao and B. Sudheer Chowdary

Transdermal patch are self contained discrete dosage forms, which when applied to the intact skin, deliver the drug through the skin at controlled rate to the systemic circulation. Ramipril transdermal patch was prepared by acrylic (2-ethylhexyl acrylate) based polymer. Methyl acrylate (monomer), vinyl acetate (copolymer) in ethanol as solvent and ramipril was dissolved or suspended in mixture of solvents constituted by one litre of propan -2-ol and 1.5 liter of ethyl acetate. The mixture was stirred, until a homogeneous mass was obtained, and this was evaporated. The composite medicated foil form the final transdermal patch. Evaluation was done by physical appearance, folding endurance, water vapour transmission, drug diffusion study, permeability studies, content uniformity and in vitro drug release.


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