Abstract

Development and Validation of HPTLC Method for Simultaneous Estimation of Domperidone in Combination with Esomeprazole Magnesium in Solid Dosage Form

Author(s): Vidya Gawande and Manisha Puranik

The present work describes high performance thin layer chromatographic method for simultaneous estimation of domperidone in combination with esomeprazole magnesium in capsule formulation. Chromatography was performed on (10 × 10 cm) silica gel F254 TLC plates using mobile phase chloroform : methanol (9 : 1 v/v) with 30 min time of saturation with filter paper. Chromatographic conditions were found to effectively separate domperidone (Rf –0.25) and esomeprazole magnesium (Rf-0.46). Standard calibration curve was found to be linear in the range 0.06- 0.3 >g/spot for domperidone and 0.08-0.4 >g/spot for esomeprazole magnesium, respectively. The proposed method was found to be accurate, precise, reproducible, economic, reliable and specific and can be used for simultaneous analysis of these drugs in capsule formulation.


Share this       
eutics.com | 523: Origin is unreachable

Error 523 Ray ID: 4e943e4a3c9caba0 • 2019-06-19 08:48:19 UTC

Origin is unreachable

You

Browser

Working
Toronto

Cloudflare

Working
eutics.com

Host

Error

What happened?

The origin web server is not reachable.

What can I do?

If you're a visitor of this website:

Please try again in a few minutes.

If you're the owner of this website:

Check your DNS Settings. A 523 error means that Cloudflare could not reach your host web server. The most common cause is that your DNS settings are incorrect. Please contact your hosting provider to confirm your origin IP and then make sure the correct IP is listed for your A record in your Cloudflare DNS Settings page. Additional troubleshooting information here.