Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerDevelopment and Evaluation of Gingko biloba L. Extract Loaded into Carboxymethylcellulose Sublingual Films| Abstract

Abstract

Development and Evaluation of Gingko biloba L. Extract Loaded into Carboxymethylcellulose Sublingual Films

Author(s): Juste Baranauskaite-Ortasoz

Oral bioavailability of flavonoids, composing G. biloba extract, is limited due its chemical complexity, which determines low aqueous-phase solubility and slow dissolution behavior of the extract (E). The sublingual films of G. biloba extract were developed using solvent casting technique. The overall research objective was to compare the effect of increasing freeze-dried G. biloba extract (GFD) concentrations (0.3, 0.4, 0.5, 0.6 g) within films on their mechanical properties, release profile of flavonoids (expressed as flavone glycosides), stability and disintegration time. Physicochemical evaluation of films were performed by scanning electron microscopy and FTIR. The higher elongation at the break and tensile strength values, quick release of flavonoids, as well as good stability were observed in formulation, coded FRG – 15 (the film sample contained 0.4 g of (GFD), 0.3 g of glycerol and 2 g of 2% CMC) (p < 0.05). Dissolution rate tests, carried to completion on FRG – 15, showed that approximately 85% of loaded flavonoid glycosides had been released. Shorter dissolution times were also noted in using FRG – 15. In particular, the release profile of flavonoid glycosides had levelled off after only 15 minutes, respectively, depicting an impressive 1.5 – 1.7 increase rate, compared to the freeze-dried control extract. The data obtained could lay the groundwork for further studies, concerning development of sublingual films as G. biloba extract-based dosage forms, which might increase the multifunctional properties and pharmacological activity closer to desired level.


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