Design and Evaluation of Matrix Tablets of Diltiazem Hydrochloride

Author(s): D. V. Ramanjaneyulu, S. Sivaprasad, K. Venugopal, C. Surendrababau, P. Hanumanna and K. Ananda Reddy

Delayed release matrix tablets of diltiazem hydrochloride were developed employing combination of hydroxypropyl methyl cellulose and stearic acid as the matrix materials in different proportions. Tablets containing 90 mg of the drug were formulated and made by entrapping the drug in a waxy carrier and then by the conventional wet granulation method. Granules prepared were evaluated for loose bulk density, tapped density, compressibility index, Hausner ratio, angle of repose and by determining the constants from a Kawakita plot. The prepared tablets were found to be of optimum hardness, uniform weight and acceptable friability. The release was found to be dependent on the relative proportion of hydroxyl propyl methyl cellulose and stearic acid. Kinetics of the drug release data was evaluated out by employing the relevant equations of first order, zero order, Higuchi square root and korsmeyer-Peppas. The drug release data suggested that the release of the drug is first order and that the drug release is diffusion controlled.

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