Controlled Release Tablets of Aceclofenac using Ethyl Cellulose by Wet Granulation and Solid Dispersion TechniqueAuthor(s): V. Lakshmi Narasaiah, Rama Devi, B. Kalyan, M. Laxmana Doss, G. Saravanan, S. Satyanand and T. Venkateswara Rao
The objective of the present study was to develop controlled release matrix tablets of aceclofenac by wet granulation and solid dispersion technique using ethyl cellulose as a rate controlled material. The granules and tablets were subjected to physicochemical properties and in vitro drug release. The physicochemical properties were found to be within the limits. The concentration of the polymer in the system was a determining factor in the control of the release rate of the drug. The in vitro drug release was found to be 93% for aceclofenac from solid dispersion formulation (A7) compared to 84% from wet granulation (A1). By comparing dissolution profiles, the release pattern followed zero order kinetics and the mechanism of drug release was governed by peppas model. The ‘n’ values were found to be more than 1 (n > 1), which indicated that the drug release was predominately controlled by super case II diffusion.