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Byrsonima crassa triterpenes and antitubercular activity

Author(s): Celio Takashi Higuchi, Miriam Sannomiya, Fernando Rogério Pavan, Wagner Vilegas, Daisy Nakamura Sato, Luis Vitor S.Sacramento, Clarice Queico Fujimura Leite

We evaluated the potential antitubercular activity of triterpenes obtained fromleaves and barks of Byrsonima crassa, a native species of Brazilian central savannah-like belt of vegetation. The structures of compounds were elucidated on the basis of spectroscopic evidence. The antitubercular activitywas determined by microplate alamar blue method(MABA). From chloroformic extracts of leaves, by bioassay guided fractionation, we obtainedmixtures of known triterpenes: α-amyrin, β-amyrin and their acetates, lupeol, oleanolic acid, ursolic acid and α-amyrinone, which exhibited minimum inhibitory concentration (MIC) ranged of 31.25- 312.25µg/mL. β-amyrin and friedelin isolated from chloroformic extract of bark showed MICof 312,25µg/mLand 125µg/mLrespectively. This is the first report of triperpenes present in B. crassa and their antimycobacterial activity.

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