Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerBenzohydrazide incorporated Imidazo [1,2-b] pyridazine: Synthesis, Characterization and in vitro Anti-tubercular Activity| Abstract

44 7460 854 031

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Abstract

Benzohydrazide incorporated Imidazo [1,2-b] pyridazine: Synthesis, Characterization and in vitro Anti-tubercular Activity

Author(s): Paidi KR, Tatipamula VB, Kolli MK and Pedakotla VR

The accumulating pharmacological importance of drug resistant pathogens has lent auxiliary urgency to new anti-tubercular compound development. In this regard, a novel series of imidazo [1,2-b] pyridazine comprising benzohydrazide derivatives have been synthesized, characterized by using spectral data and screened for anti-tuberculosis activity. The anti-tubercular activity of the synthesized compounds (6a-l) was determined by microplate alamar blue assay and the outcomes were screened in vitro against Mycobacterium tuberculosis H37Rv strain. Compounds 6a-l exhibited good to potent anti-tubercular activity when compared with the standard first line anti- tuberculosis drugs (ciprofloxacin, pyrazinamide and streptomycin). Some of the tested compounds exhibited highest inhibitory activity at 1.6 μg/mL minimal inhibition concentration.


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