Antioxidant and Anti-Inflammatory Activity of 3,3-Dimethyl 2,6-Dimethyl Piperidine 4-One Oxime

Author(s): K. Tharini and P. Sangeetha

Antioxidant and anti-inflammatory activity of 1,3-dimethyl 2,6-diphenyl piperidine 4-one oxime were investigated. In vitro antioxidant activity like DPPH and superoxide radical scavenging activity were investigated by standard methods. Results of the present study indicates that higher dose of 3, 3-dimethyl 2,6-dimethyl piperidine 4-one oxime has potent anti-inflammatory activity close to standard drug. The above results confirmed that 3,3-dimethyl 2,6-dimethyl piperidine 4-one oxime possess significant antiinflammatory activity as compared to standard drug dexamethasone. The antioxidant activity of 3,3- dimethyl 2,6-dimethyl piperidine 4-one oxime was concentration dependent and approximately comparable to commercial synthetic antioxidants as ascorbic acid. Anti-inflammatory activity was evaluated using the carrageenan induced rat paw oedema. After 12 hrs fast rats, were divided into five groups of six each. Each animal was marked for identification and regularly monitoring. Group I served as control group received carrageenan only. Group II, III and IV animals received 3,3-dimethyl 2,6-dimethyl piperidine 4-one oximeat a dose of 100, 250 and 500 mg/Kg orally. Group V was orally administered 2 mg/Kg (ip) dexamethasone as a standard drug. On the basis of the results, it is clearly indicated that 3,3- dimethyl 2,6-dimethyl piperidine 4-one oxime had powerful anti-inflammatory and in vitro antioxidant activity.

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