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Antidiabetic and hypolipidemic effect of extract of leaves of Aegle Marmelos in alloxan induced diabetic rats

Author(s): N.B.Chaudhari, G.D.Toke, J.D.Fegade, N.M.Jawale, R.Y.Chaudhari, V.R.Patil

In the tribal people of Satpuda Valley, leave’s powder of the Aegle marmelos is used in diabetis mellitus, but no systematic and scintific investigations were conducted on this powder for anti-diabetic activity. In the present study, hydro-alchoholic extract of the leaves of Aegle marmelos was collected and subjected for evaluation of anti-daibetic activity in alloxan induced diabetic rats. The rats of group-II to V were divided with alloxan monohydrate at a dose of 200 mg/kg body weight subcutaneously. After fortnight the rats of groups III,IV and V were orally recived 25, 50 and 100 ml/kg of hydro-alchoholic extract of the leaves of Aegle marmelos daily respectively. The duration of experiment is 45 days. At the end of experimental period, blood was estimated for blood glucose level and the lipid profile. The result shows significant decrease in level of glucose, Serum cholesterol, Triglycerides and Phospholipids in the rats treated with hydro- alchoholic extract of the leaves of Aegle marmelos at a dose of 100ml/ kg as compare to untreated rats. Hence, the hydro-alchoholic extract of the leaves of Aegle marmelos has exhibited anti-diabetic and hypolipidemic activity.

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