Synthesis, Spectral, DNA Cleavage and Antimicrobial Studies of Homo Trinuclear Cu (II), Ni (II) and Mn (II) Complexes

Author(s): S. Prasad, P. Jayaseelan and R. Rajavel

The template synthesis of benzil, p-phenylenediamine and metal salt in 1 : 2 : 1 molar ratio yielded the mononuclear Schiff base complex with N4 donors. The mononuclear complex has been used as a ligand, for further condensation of 2-aminobenzaldehyde and metal salts as a same kind, the stable homo trinuclear Cu (II), Ni (II) and Mn (II) Schiff base complexes were obtained. The characterization and nature of bonding of the trinuclear complexes have been deduced from elemental analysis, molar conductivity, FT-IR, UV-visible, magnetic and EPR studies. The pUC18 DNA gel electrophoresis experiment was conducted at room temperature using our synthesised trinuclear complexes in the presence of H2O2 as an oxidant. As can be seen from the results at high concentration, all the three homo trinuclear complexes exhibit nuclease activity. The in vitro biological screening effects of the investigated compounds were tested against the gram negative and gram positive bacteria by disc diffusion method. A comparative study of minimum inhibitory concentration values of the complexes indicate that the all trinuclear metal complexes exhibit higher antibacterial activity.

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