In this study, stems and leaves of Salvadora persica were collected from trees grown at Ahaggar in south Algeria. They were powdered and extracted why to assess, the one hand, total phenolic, tannin and flavonoid content and, on the other hand, antioxidant and antibacterial activities of (ethyl acetate fraction, butanolic fraction and alkaloids total). The results showed higher levels of total phenolic, tannin and flavonoid content in leaves (67.32 ± 0.17 and 39.31 ± 3.81 mg PE/g DW and 0.47 ± 0.00 mg RE/g DW). Higher Free Radical Scavenging and iron reducing power of leaves ethyl acetate extractwas observed (IC50, 11.8 ± 0.07 ïg/ml and 480 ± 6 ìg/ml respectively). On the contrary of antioxidant activity, the strongest antibacterial activity of Salvadora persica extract was exhibited by StemsAlkaloids extract against Bacillus cereusATCC 11778 (17mmat 20mg/ml).