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Abstract

RP-HPLC Method Development and Validation for Simultaneous Estimation of Thiocolchicoside and Lornoxicam in Tablet Dosage Form

Author(s): B. Rajani and K. Mukkanti

A simple and cost effective reverse phase high performance liquid chromatography method was developed for simultaneous estimation of Thiocolchicoside and Lornoxicam in tablet dosage form. In this mehod, Chromatography was carried out on an Hypersil BDS, C-18 column (4.6 x 250 mm, 5 μ particle size) with a mobile phase composed of acetonitrile -phosphate buffer pH-3 in Gradient technique at a flow rate of 1.0 mL/min. Detection was carried out using a PDA detector at 260 nm. Validation parameters were studied as per ICH guidelines. The retention times for Thiocolchicoside and Lornoxicam are 2.3 min and 6.1 min, respectively. The linearity range for Thiocolchicoside and Lornoxicam are 10-60 µg/mL and 20-120 µg/Ml, respectively. The percentage recoveries of Thiocolchicoside and Lornoxicam are 99.96% and 100.65%, respectively. The correlation coefficients for both components are close to 1. This method is fast, accurate, precise and sensitive hence it can be employed for routine quality control of tablets containing both drugs in industries


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  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

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