The plant Samadera indica is widely used as an antimicrobial agent from ancient times. According to literature, this plant has been less explored for its antimicrobial activity. In this study, the antibacterial activity of this plant was studied using hexane and toluene extracts by agar well diffusion method. Phytochemical study was carried out to find the presence of various phytoconstituents. Zone of inhibition was observed, which led to the conclusion that these extracts of Samadera indica possess antibacterial activity.