The present work was undertaken to assess the potential of Argyreia speciosa as a nootropic and anti-cholinesterase agent in mice. Elevated plus maze and passive avoidance paradigm were employed to assess short-term and long term memory. The whole brain acetyl cholinesterase activity (AChE) was also assessed. Two doses (100 and 200mg/kg, p.o.) of aqueous extract of A. speciosa were administered orally for 6 successive days to both young and aged mice. A. speciosa decreased transfer latencies and increased step down latencies in both young and aged mice A. speciosa (100 and 200mg/kg, p.o.) successfully reversed amnesia induced by diazepam, scopolamine and natural ageing. A. speciosa significantly decreased AChE levels in the whole brain homogenate indicating its potential in the attenuation of learning and memory deficits especially in the aged mice.