44 7460 854 031

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Formulation and Evaluation of Floating Tablets of Gliclazide Employing HPMC and Carbopol

Author(s): K. P. R. Chowdary and S. Areefulla Hussainy

The objective of the present study is to evaluate HPMC K100M, HPMC K4M and carbopol 934P as matrix formers in this design of floating tablets of gliclazide, a poorly water soluble drug. Floating tablets of gliclazide (60 mg) were formulated employing (i) HPMC K100M (ii) HPMC K4M and (iii) Carbopol 934P as matrix formers at 30% and 50% strength, sodium bicarbonate at 7.5%, 10% & 12.5% strength as gas generating agent and bees wax (10%) as floating enhancer and the tablets were evaluated for floating and drug releases characteristics. Gliclazide floating tablets formulated employing HPMC K100M and HPMC K4M as matrix formers at 50% strength and containing sodium bicarbonate (12.5%) as gas generating agent exhibited floating over 31 to 44 h with a floating lag time of less than 1 min. These floating tablets also gave slow and controlled release of gliclazide over 24 h and were found suitable for once a day administration (24 h). HPMC K100M and HPMC K4M were better suitable as matrix formers than Carbopol 934P for floating tablets of gliclazide, a poorly water soluble drug.


Share this       
Google Scholar citation report
Citations : 9398

International Journal of Chemical Sciences received 9398 citations as per Google Scholar report

Indexed In

  • Google Scholar
  • Open J Gate
  • China National Knowledge Infrastructure (CNKI)
  • Cosmos IF
  • Geneva Foundation for Medical Education and Research
  • ICMJE

View More