An electrochemical sensor based on the electrocatalytic activity of functionalized natural phosphate for sensitive detection of paracetamol is presented. The electrochemical behaviors of paracetamol on natural phosphate modified carbon paste electrode (NP-CPE) were investigated by cyclic voltammetry and square wave voltammetry. The results showed that the natural phosphate modified electrode exhibited excellent electrocatalytic activity to paracetamol. A quasi-reversible redox process of paracetamol at the modified electrode was obtained. Such electrocatalytic behavior of natural phosphate is attributed to its unique physical and chemical properties, subtle electronic characteristics, attractive interaction, and strong adsorptive capability. This electrochemical sensor shows an excellent performance for detecting paracetamol. The sensor shows great promise for simple, sensitive, and quantitative detection and screening of paracetamol.