The present study was aimed to investigate the analgesic and antipyretic activity of alcoholic and aqueous extracts of fruits of ZizyphusOenoplia in standard experimental models in mice and albino rats following oral route of administration. The centrally acting analgesic activity of the extracts was evaluated using EddyÂs hot plate method, where as peripheral analgesic activity by acetic acid induced writhing Method. The extracts were studied for antipyretic activity by yeast induced hyperthermia in rats. Here the alcoholic extract of fruits of Zizyphus Oenoplia was found to have more significant analgesic effect in both centrally and peripherally than aqueous extract when compared to control. Diclofenac sodium was used as standard reference drug. Similarly the alcoholic extract showed a significant antipyretic activity than aqueous extract when compared to control. Paracetamol was used as standard reference drug.