Obesity-related glomerulopathy (ORG) is mostly being a secondary style of glomerular disease that may occur in people with fats. However, absolutely the risk for an obese individual to develop progressive renal deterioration is low. Therefore, fat alone seems to be inadequate to develop such severe renal injury, and there are mostly different factors that contribute to the growth of this entity. The glomerular hyper filtration found in patients with ORG has been postulated to show structural abnormalities in glomeruli, like glomerulomegaly and focal segmental focal segmental glomerular sclerosis, in a very analogous manner to delimit in patients with reduced renal mass. In fact, recent studies counsel that a deduction in nephron mass is concerned in patients with ORG and synergistically contributes to the development of this renal complication with obesity-induced changes in renal hemodynamics.