Novel Bone Marrow Articles Open Access

In bone marrow transplants, stem cells residing in the donors' bone marrow are mobilized to the blood using drugs in order to facilitate collection. “Our new method of harvesting stem cells requires only a single injection and mobilizes the cells needed in 15 minutes; so in the time it takes to boil an egg, we are able to acquire the number of stem cells produced by the current standard five-day protocol,” said Jonathan Hoggatt, Ph.D., a principal faculty member of the HSCI, member of the MGH Cancer Center and Center for Transplantation Sciences, and lead author of the Cell paper. PET studies are used on a regular basis in the initial staging of lymphoma patients-pretreatment-and assess response to treatment and prognosis. BM involvement is synonymous of a stage IV and is associated with a worse short and long-term prognosis. Concordant BMu and BM involvement confirmed by a biopsy has been reported to correlate with worse outcomes.

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