Neuronal Marker Journals

A Neuronal lineage marker is an endogenous tag that is expressed in different cells along neurogenesis and differentiated cells such as neurons. It allows detection and identification of cells by using different techniques. A neuronal lineage marker can be DNA, mRNA or RNA expressed in a cell of interest. It can also be a protein tag, as a partial protein, a protein or an epitope that discriminates between different cell types or different states of a common cell. An ideal marker is specific to a given cell type in normal conditions and/or during injury. Cell markers are very valuable tools for examining the function of cells in normal conditions as well as during disease. The discovery of various proteins specific to certain cells led to the production of cell-type-specific antibodies that have been used to identify cells. Using antibodies against various cell components, investigators are able to identify cells expressing a neuronal phenotype and, moreover, collect information regarding their morphological characteristics and expression of specific proteins. Other approaches exists to define neuronal cell types. For example, physiological optical tagging sequencing (PhOTseq) relies on the initial GCaMP calcium imaging labeling of neurons through activation and then the permanent labeling of specific neurons with photoactivatable.

 

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