Nano Science & Nano Technology: An Indian Journal
ISSN (PRINT): 0974-7494

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Journal On Ligand Based Drug Designing

LBDD may be a general approach to elucidate the connection of a compound's structure and physicochemical attributes to its biological activity. The resulting structure-activity relationship (SAR) may then act because the basis for the prediction of compounds with improved biological attributes. Ligand based drug design is an approach used in the absence of the receptor 3D information and it relies on knowledge of molecules that bind to the biological target of interest. The two most common techniques for determining three-dimensional structures of protein targets for drugs are X-ray crystallography and nuclear magnetic resonance spectroscopy. Novel high-throughput technologies in drug discovery that utilize these techniques will be discussed. Ligand-based virtual screening methods use the information present in known active ligands rather than the structure of a target protein for both lead identification and optimization. A ligand-based computational method involves two essential elements: an efficient similarity measure and a reliable scoring method. In the absence of three-dimensional (3D) structures of potential drug targets, ligand-based drug design is one among the favored approaches for drug discovery and lead optimization. 3D structure-activity relationships (3D QSAR) and pharmacophore modeling are the foremost important and widely used tools in ligand-based drug design which will provide crucial insights into the character of the interactions between drug target and ligand molecule and supply predictive models suitable for lead compound optimization. 

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Citations : 154

Nano Science & Nano Technology: An Indian Journal received 154 citations as per Google Scholar report

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