In this special collection of research results, we present a group of original works performed by employing natural compounds as tools to approach immunomodulation at different levels and against different diseases. Natural compounds have contributed enormously to immunomodulatory therapeutics. Since ancient times, natural medicines have constituted treatments with minimal side effects. There are thousands of natural compounds that are known to influence the immune system by either affecting the functions of immune cells or affecting antibody secretion to control the infection and to maintain immune homeostasis. The relevance of this research would be crucial to the search for better treatments, both to complement those that already exist and to develop new strategies for the prevention and treatment of immune-related diseases. Therefore, it is interesting to dissect the molecular mechanisms of the immunomodulatory effects of natural compounds and to discover novel promising candidates that can be used in the future immunotherapeutic strategies.

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