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Hereditary Colorectal Open Access Articles

Hereditary colorectal cancer involves a cancer gene being passed from parent to child. However, it is unclear which gene causes the disease. If more than one family member has colon or rectal cancer, it could mean that the potential for developing this form of cancer has been passed from one generation to the next. The most important step leading to the diagnosis of a hereditary cancer syndrome is the compilation of a thorough family history of cancer.2-4 A patient and his or her key relatives, working either alone or with a trained nurse or genetic counselor, can compile such a detailed family history. The focus should be on identifying cancer of all types and sites; the family member's age at the onset of cancer; any pattern of multiple primary cancers; any association with phenotypic features that may be related to cancer, such as colonic adenomas; and documentation of pathological findings whenever possible. This information will frequently identify a hereditary colorectal cancer syndrome in the family, should it exist. Molecular genetic testing may then provide verification of the diagnosis, when a germ-line mutation is present in the family.5,6 The primary care physician may wish to refer the patient to a hereditary-cancer specialist and genetic Counselor for further evaluation should there be any remaining question about the disorder's clinical or molecular genetic diagnosis and the need for targeted surveillance and management.. Open access is a wide universal development that tries to concede free and open online access to scholarly data, for example, distributions and information. A distribution is characterized 'open access' when there are no budgetary, lawful or specialized boundaries to getting to it - in other words when anybody can peruse, download, duplicate, disperse, print, look for and search inside the data, or use it in instruction or in some other path inside the legitimate understandings.

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