Acta Chimica and Pharmaceutica Indica
ISSN: 2277-288X

Graves Disease

Graves' disease is an autoimmune disease that affects the thyroid gland. Your thyroid is a small gland at the base of your neck. In a person with Graves' disease, the immune system makes antibodies that cause the thyroid to make more thyroid hormone than the body needs. The inheritance pattern of Graves disease is unclear because many genetic and environmental factors appear to be involved. However, the condition can cluster in families, and having a close relative with Graves disease or another autoimmune disorder likely increases a person's risk of developing the condition. Graves' disease is an autoimmune disorder, in which the body produces antibodies to the receptor for thyroid-stimulating hormone. (Antibodies to thyroglobulin and to the thyroid hormones T3 and T4 may also be produced.) These antibodies cause hyperthyroidism because they bind to the TSHr and chronically stimulate it.

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Citations : 968

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