All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

Visible Spectrophotometric Methods for the Determination of Baclofen

Author(s): R. Mrutyunjaya Rao, T. Siva Rao, C. S. P. Sastry and U. Viplava Prasad

Three simple and sensitive methods (methods A, B and C) for the determination of baclofen (BC) in bulk samples and formulations are described. Mehod A (λmax 520 nm) is based on the reaction BC with safranin O (SFNO) to form an ion-association complex , which is extractable into chloroform aqueous phase; method B (λmax520 nm) is based on the reaction of drug BC with brucine and sodium metaperiodate (NaIO4) under acidic conditions forming coloured bruciquininone derivatives, while method C (λmax 450 nm) is based on the reaction of drug with 2,3-dichloro – 5-6-dicyno-1,4-benzo-quinone (DDQ). The concentration measurements are reproducible within a relative standard deviation of 1%.


Share this       

Recommended Conferences

Flyer