Visible Spectrophotometric Determination of Bicalutamide in Bulk Drug and Pharmaceutical Formulations

Author(s): V. Murali Balaram, J. Venkateswara Rao, M. Mushraff Ali Khan, J. V. C. Sharma and K. Sreedevi

Two new simple, sensitive and cost effective visible spectrophotometric methods were developed for the estimation of bicalutamide in both; bulk drug samples and formulations. The first method was based on the oxidative coupling of the drug with the reagent namely 3-methyl-2- benzothiazolinone hydrazone hydrochloride (MBTH, Method A) and ferric chloride solution. Second method was based on reaction of 1, 2 – naphthoquinone - 4 - sulphonic acid (NQS, Method B). The absorbance of the chromogens was measured at their respective absorption maxima at 630 nm for MBTH and 453 nm for NQS against the corresponding reagent blank. The methods obeyed Beer’s law between 10-60 ;g/mL for MBTH and 2.5-25 ;g/mL for NQS. The results of the recovery experiments indicated that average recovery was above 99.83%. The interference studies also revealed the common excipients and other additives usually present in pharmaceutical dosage forms did not interfere in the proposed methods. The proposed methods are precise, accurate, sensitive and cost effective and can be used in routine analysis in quality control laboratories.

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