Utility of Halogenated 2,4-Dioxobutanoate Derivative in the Synthesis of Nitrogeneous Heterocycles and their Biological Evaluation

Author(s): Naqui-Jahan Siddiqui

The reaction of 7-bromo - 5-chloro-2-acetyl-3-methylbenzofuran (1) with diethyloxalate in presence of NaOMe and NaOEt afforded (2) and (3) , respectively by Claisen’s condensation reaction. Treatment of the transesterified halogenated 2,4-dioxobutanoate (2) with different nucleophilic reagents undergo cyclocondensation to afford the corresponding (4) , (5) , (6) , (7) and (8) . The structures of all the newly synthesized compounds (2-8) have been characterized by their elemental and spectral studies such as IR, 1 H NMR, 13 C NMR and MS. The newly synthesized compounds were tested for their antimicrobial activities against two gram positive; two gr am negative bacteria and one fungus.

Share this       
izmir escort izmir escort bursa escort antalya escort izmir escort porno porno izle türk porno eskişehir escort bartın escort burdur escort izmir escort bursa escort porno indir izle istanbul escort istanbul escort bayan escort izmir