Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerThe Differential Urinary Metabolite Profiling of Intellectual Disability Disorders Using Untargeted Metabolomics Approach| Abstract
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Abstract

The Differential Urinary Metabolite Profiling of Intellectual Disability Disorders Using Untargeted Metabolomics Approach

Author(s): Vidya Nikam, Suvidya Ranade

Intellectual disability (ID) is a disorder characterized by cognitive delays. Inborn errors of metabolism constitute an important subgroup of ID for which a number of treatments have become available. We aimed to identify potential urine biomarkers of inherited metabolic disorders from the children with intellectual disability using an untargeted Ultra Performance Liquid Chromatography coupled to Mass Spectroscopy (UPLC-MS) based metabolomics approach. All of the patients were having ID, with IQ less than 70 and no recognizable symptoms for the condition. Eleven compounds have been identified that are up regulated in the ID cohort, three of which are previously reported namely Dopamine, Glutarylglycine and Suberic acid. The physiological significance of these markers is discussed. In conclusion, the results of the study indicate that urinary metabolite analysis of ID using sophisticated analytical high throughput techniques may be an important tool to achieve an early diagnosis and therapy of several metabolic defects, and reflect the underlying biology of ID.


Share this