Synthesis of Some New 3-Substituted - 4H-1, 2, 4-triazoles and their Evaluation for Antimicrobial Activity

Author(s): P. K. Goyal, A. Bhandari, A. C. Rana and D. S. Bele

Some new derivatives of 3-substituted -4H-1, 2, 4- triazoles 4 (a-e) were synthesized through the reaction of 4-alkyl diazo substituted 4H-1, 2,4- triazoles- 3-thiole with different aliphatic and aromatic amines to yield the titled compounds. Structure of new compounds were verified on the basis of spectral (UV, IR, 1H-NMR, MS) data and elemental (C, H, N, S) analysis. Antimicrobial activity of all the triazole derivatives were evaluated in vitro against the bacteria S. aureus, B. subtilis, P. aeruginosa, E. coli and fungi A. fumigatus and C. albicans. Most of the compounds showed potent and significant results compared to standard ciprofloxacin and fluconazole.

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