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Synthesis of Novel Pyrazoline Derivatives Containing Imidazo [1, 2-a] Pyridines Moiety Via Lewis Base Catalyst and their Antimicrobial Activity

Author(s): Viral Shah, Nainesh Kansagara, Jagdish Godhasra and Mahesh Patel

The series of 3-(3-aryl-4, 5-dihydro-1H-pyrazol-5-yl)-6-methyl-2-(4-methylphenyl)imidazo [1, 2-a]pyridines (2a–l) have been synthesized with better yield within few minutes by using of triethylamine as a catalyst by the condensation of 1-aryl-3-[6-methyl-2-(4-methylphenyl) imidazo [1, 2- a] pyridin-3-yl]prop-2-ene-1-ones (1a–l) with hydrazine hydrate. A considerable increase in the reaction rate has been observed, with better yields. Some of these compounds showed potential antimicrobial activity.

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