Synthesis of 6-Chloroflavone from 4-Chlorophenol and their Biocidal Activity

Author(s): Vaishali B Adhau

Flavones are the organic compounds essential for human body found naturally in cereals and herbs. Usually, flavones have been prepared by Baker-Venkatraman rearrangement, which involves the conversion of 2-hydroxyacetophenones into benzoyl esters followed by rearrangement in base to give 1, 3- diketone as a reaction intermediate, which upon cyclization under acidic conditions to afford respective flavones. The present work deals with the synthesis of 6-chloroflavone from 4-chlorophenol and it characterization on the basis of UV-Vis, IR and 1H-NMR spectral data. Also the biocidal activity of synthesized compound have been evaluated against the growth of microorganisms using paper disc method and compared with streptomycin as a standard.

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