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Synthesis, Characterization, Thermal, DNA binding, DFI, Antioxidant and Anticancer Studies of Bis (methylphenylmethanamine) Dichloroplatinum Complex

Author(s): Rakesh Kumar Ameta, Nitin Kumar Sharma, Chetan B Sangani and Man Singh

Bis (methylphenylmethanamine) dichloroplatinum (MMCP), a new Pt (II) complex, has been synthesized and characterized with different spectroscopic means. Thermal analysis expressed its heat absorption capacity and weight loss with respect to temperature. UV/Vis study performed in DMF and DMSO/phosphate buffer with 10, 30, 50, 70 and 90 μM that inveterate stability of the complex. The DNA binding activity studied with absorption spectroscopy, viscosity, surface tension, sound velocity, refractive index, conductivity and zeta potential which has confirmed its strong DNA interaction. The DFI study with comparison of viscosity and surface tension has been analyzed which explored its anticancer nature. The DPPH* scavenging effect was carried out with 50, 100, 150, 200, 250, 300, 350 and 400 μM which showed its antioxidant activity due to its terminating action against reactive species. In vitro anticancer results on MCF-7 cell line showed its anticancer activity.

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