Parası kalmadığı için otobüse binemiyordur ailesi porno izle ona daha yeni para gönderdiği için tekrar porno istemeye utanınca mecburen otostop çekmek için youporn çantasını alarak yol kenarına gelir etekli porno liseli türk kız yol kenarında dururken yanına yaklaşan porno kibar bir gencin onu gideceği yere kadar bırakmak porno izle istemesine çok mutlu olur arabaya bindiklerinde gideceği yer ile porno arabayı kullanan adamın gittiği yer arasında çok mesafe sex izle farkı olduğunu anlayan türk kız bu yaptığı porno indir iyilik karşısında arabada ona memelerini açar porno sapıklaşan adam yol kenarındaki hotelde durarak porno izle üniversiteli otostop çeken türk kızına odada sakso çektirip sikerSynthesis, Characterization of Polyhedral Oligomeric Silsesquioxane-Metronidazole Conjugate and Determination of Antibacterial, Biocompatible Properties| Abstract

Abstract

Synthesis, Characterization of Polyhedral Oligomeric Silsesquioxane-Metronidazole Conjugate and Determination of Antibacterial, Biocompatible Properties

Author(s): Idil Karaca Acari*, Ismet Yilmaz, Suleyman Koytepe, Burhan Ates, Sevgi Balcıoglu and Turgay Seckin

The aim of the present study is to synthesize the antibacterial and biocompatible novel polyhedral oligomeric silsesquioxane-metronidazole (POSS-MTZ) conjugate with condensation reaction from chloro-functional polyhedral oligomeric silsesquioxane and metronidazole. The prepared chloro-functional POSS metronidazole and POSS-metronidazole structures were characterized for their chemical structure; morphology and thermal behaviour by employing fourier transform infrared spectroscopy, 1H nuclear magnetic resonance spectroscopy, scanning electron microscope/energy dispersive X-ray spectroscopy and thermo gravimetric/differential thermal analysis, differential scanning calorimetric analyzer techniques. In addition, the antibacterial properties of the synthesized POSS-MTZ conjugate were tested with broth micro dilution methods on E.coli and S.aureus bacteria. The synthesized POSS-MTZ conjugate shows a statistically significant (p<0.001) antibacterial increase in both E.coli and S.aureus bacteria compared to pure metronidazole (MTZ). Biocompatibility of the POSS-MTZ conjugate was detected in an in vitro cell culture system with an MTT test on L929 mouse skin fibroblast cells. POSS-MTZ conjugates are not cytotoxic. POSS-MTZ conjugate with good biocompatibility and high antibacterial activity can be modified and used for medical and industrial purposes (e.g. wound dressing material, medical surface coating, packaging etc.


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Citations : 748

Acta Chimica and Pharmaceutica Indica received 748 citations as per Google Scholar report

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