Synthesis, Characterization of Polyhedral Oligomeric Silsesquioxane-Metronidazole Conjugate and Determination of Antibacterial, Biocompatible Properties

Author(s): Idil Karaca Acari*, Ismet Yilmaz, Suleyman Koytepe, Burhan Ates, Sevgi Balcıoglu and Turgay Seckin

The aim of the present study is to synthesize the antibacterial and biocompatible novel polyhedral oligomeric silsesquioxane-metronidazole (POSS-MTZ) conjugate with condensation reaction from chloro-functional polyhedral oligomeric silsesquioxane and metronidazole. The prepared chloro-functional POSS metronidazole and POSS-metronidazole structures were characterized for their chemical structure; morphology and thermal behaviour by employing fourier transform infrared spectroscopy, 1H nuclear magnetic resonance spectroscopy, scanning electron microscope/energy dispersive X-ray spectroscopy and thermo gravimetric/differential thermal analysis, differential scanning calorimetric analyzer techniques. In addition, the antibacterial properties of the synthesized POSS-MTZ conjugate were tested with broth micro dilution methods on E.coli and S.aureus bacteria. The synthesized POSS-MTZ conjugate shows a statistically significant (p<0.001) antibacterial increase in both E.coli and S.aureus bacteria compared to pure metronidazole (MTZ). Biocompatibility of the POSS-MTZ conjugate was detected in an in vitro cell culture system with an MTT test on L929 mouse skin fibroblast cells. POSS-MTZ conjugates are not cytotoxic. POSS-MTZ conjugate with good biocompatibility and high antibacterial activity can be modified and used for medical and industrial purposes (e.g. wound dressing material, medical surface coating, packaging etc.

Share this       

Recommended Conferences

Annual Congress on Pharmacology & Toxicology

Webinar, Webinar